| # | Player | Runs | Balls Faced | 4s | 6s | SR | Against | Venue | Date |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Babar Azam | 122 | 59 | 15 | 4 | 206.77 | South Africa | Centurion | 14-Apr-2021 |
| 2 | Ahmed Shehzad | 111 | 62 | 10 | 5 | 179.03 | Bangladesh | Mirpur | 30-Mar-2014 |
| 3 | Babar Azam | 110 | 66 | 11 | 5 | 166.66 | England | Karachi | 22-Sep-2022 |
| 4 | Hasan Nawaz | 105 | 45 | 10 | 7 | 233.33 | New Zealand | Auckland | 21-Mar-2025 |
| 5 | Mohammad Rizwan | 104 | 64 | 6 | 7 | 162.50 | South Africa | Lahore | 11-Feb-2021 |
| 6 | Babar Azam | 101 | 58 | 11 | 3 | 174.13 | New Zealand | Lahore | 15-Apr-2023 |
| 7 | Mohammad Hafeez | 99 | 57 | 10 | 5 | 173.68 | New Zealand | Hamilton | 20-Dec-2020 |
| 8 | Ahmed Shehzad | 98 | 64 | 6 | 6 | 153.12 | Zimbabwe | Harare | 24-Aug-2013 |
| 9 | Mohammad Rizwan | 98 | 62 | 7 | 4 | 158.06 | New Zealand | Rawalpindi | 24-Apr-2023 |
| 10 | Saim Ayub | 98 | 57 | 11 | 5 | 171.92 | South Africa | Centurion | 13-Dec-2024 |
| 11 | Babar Azam | 97 | 58 | 13 | 1 | 167.24 | West Indies | Karachi | 02-Apr-2018 |
| 12 | Umar Akmal | 94 | 54 | 9 | 4 | 174.07 | Australia | Mirpur | 23-Mar-2014 |
| 13 | Mohammad Rizwan | 91 | 60 | 5 | 3 | 151.66 | Zimbabwe | Harare | 25-Apr-2021 |
| 14 | Fakhar Zaman | 91 | 46 | 12 | 3 | 197.82 | Australia | Harare | 08-Jul-2018 |
| 15 | Mohammad Rizwan | 90 | 63 | 6 | 2 | 142.85 | New Zealand | Christchurch | 19-Jan-2024 |
| 16 | Babar Azam | 90 | 58 | 13 | 1 | 155.17 | South Africa | Johannesburg | 03-Feb-2019 |
| 17 | Sarfaraz Ahmed | 89 | 49 | 10 | 3 | 181.63 | Scotland | Edinburgh | 12-Jun-2018 |
| 18 | Ahmed Shehzad | 89 | 55 | 8 | 3 | 161.81 | World-XI | Lahore | 15-Sep-2017 |
| 19 | Mohammad Rizwan | 89 | 59 | 10 | 3 | 150.84 | New Zealand | Napier | 22-Dec-2020 |
| 20 | Mohammad Rizwan | 88 | 51 | 5 | 4 | 172.54 | England | Karachi | 22-Sep-2022 |
| 21 | Mohammad Rizwan | 88 | 67 | 9 | 1 | 131.34 | England | Karachi | 25-Sep-2022 |
| 22 | Misbah-ul-Haq | 87 | 53 | 3 | 5 | 164.15 | Bangladesh | Karachi | 20-Apr-2008 |
| 23 | Babar Azam | 87 | 59 | 7 | 3 | 147.45 | England | Lahore | 30-Sep-2022 |
| 24 | Mohammad Rizwan | 87 | 45 | 10 | 3 | 193.33 | West Indies | Karachi | 16-Dec-2021 |
| 25 | Mohammad Hafeez | 86 | 52 | 4 | 6 | 165.38 | England | Manchester | 01-Sep-2020 |
| 26 | Mohammad Hafeez | 86 | 51 | 9 | 4 | 168.62 | South Africa | Centurion | 03-Mar-2013 |
| 27 | Babar Azam | 86 | 52 | 10 | 2 | 165.38 | World-XI | Lahore | 12-Sep-2017 |
| 28 | Babar Azam | 85 | 49 | 8 | 3 | 173.46 | England | Nottingham | 16-Jul-2021 |
| 29 | Mukhtar Ahmed | 83 | 45 | 12 | 3 | 184.44 | Zimbabwe | Lahore | 22-May-2015 |
| 30 | Mohammad Rizwan | 82 | 61 | 10 | 1 | 134.42 | Zimbabwe | Harare | 21-Apr-2021 |
| 31 | Babar Azam | 82 | 55 | 9 | 1 | 149.09 | Zimbabwe | Rawalpindi | 07-Nov-2020 |
| 32 | Mohammad Rizwan | 79 | 55 | 6 | 3 | 143.63 | India | Dubai (DICS) | 24-Oct-2021 |
| 33 | Mohammad Rizwan | 79 | 50 | 8 | 4 | 158.00 | Namibia | Abu Dhabi | 02-Nov-2021 |
| 34 | Babar Azam | 79 | 53 | 11 | - | 149.05 | New Zealand | Christchurch | 08-Oct-2022 |
| 35 | Babar Azam | 79 | 58 | 7 | 2 | 136.20 | New Zealand | Dubai (DICS) | 04-Nov-2018 |
| 36 | Babar Azam | 79 | 53 | 9 | 2 | 149.05 | West Indies | Karachi | 16-Dec-2021 |
| 37 | Mohammad Rizwan | 78 | 57 | 6 | 1 | 136.84 | Hong Kong | Sharjah | 02-Sep-2022 |
| 38 | Mohammad Rizwan | 78 | 50 | 7 | 2 | 156.00 | Bangladesh | Christchurch | 07-Oct-2022 |
| 39 | Mohammad Rizwan | 78 | 52 | 10 | - | 150.00 | West Indies | Karachi | 13-Dec-2021 |
| 40 | Fakhar Zaman | 78 | 40 | 6 | 6 | 195.00 | Ireland | Dublin | 12-May-2024 |
| 41 | Sarfaraz Ahmed | 76 | 64 | 8 | 2 | 118.75 | New Zealand | Dubai (DICS) | 04-Dec-2014 |
| 42 | Mohammad Rizwan | 76 | 57 | 5 | 3 | 133.33 | England | Manchester | 20-Jul-2021 |
| 43 | Mohammad Rizwan | 75 | 46 | 6 | 4 | 163.04 | Ireland | Dublin | 12-May-2024 |
| 44 | Shoaib Malik | 75 | 54 | 8 | 2 | 138.88 | England | Sharjah | 30-Nov-2015 |
| 45 | Babar Azam | 75 | 42 | 6 | 5 | 178.57 | Ireland | Dublin | 14-May-2024 |
| 46 | Mohammad Rizwan | 74 | 50 | 9 | 2 | 148.00 | South Africa | Johannesburg | 10-Apr-2021 |
| 47 | Salman Butt | 74 | 56 | 6 | 3 | 132.14 | Canada | King City (NW) | 10-Oct-2008 |
| 48 | Mohammad Rizwan | 74 | 62 | 5 | 3 | 119.35 | South Africa | Durban | 10-Dec-2024 |
| 49 | Mohammad Rizwan | 73 | 47 | 5 | 2 | 155.31 | South Africa | Centurion | 14-Apr-2021 |
| 50 | Kamran Akmal | 73 | 55 | 8 | 1 | 132.72 | Bangladesh | Gros Islet | 01-May-2010 |
| 51 | Salman Butt | 73 | 46 | 8 | 2 | 158.69 | Bangladesh | Gros Islet | 01-May-2010 |
| 52 | Fakhar Zaman | 73 | 42 | 9 | 3 | 173.80 | Australia | Harare | 05-Jul-2018 |
| 53 | Imran Nazir | 72 | 36 | 9 | 3 | 200.00 | Bangladesh | Pallekele | 25-Sep-2012 |
| 54 | Mohammad Hafeez | 71 | 48 | 6 | 3 | 147.91 | Zimbabwe | Harare | 16-Sep-2011 |
| 55 | Mohammad Rizwan | 71 | 51 | 6 | 2 | 139.21 | India | Dubai (DICS) | 04-Sep-2022 |
| 56 | Ahmed Shehzad | 70 | 50 | 6 | 1 | 140.00 | Zimbabwe | Harare | 23-Aug-2013 |
| 57 | Babar Azam | 70 | 49 | 7 | - | 142.85 | Namibia | Abu Dhabi | 02-Nov-2021 |
| 58 | Mohammad Hafeez | 69 | 36 | 5 | 4 | 191.66 | England | Manchester | 30-Aug-2020 |
| 59 | Mohammad Rizwan | 69 | 56 | 4 | - | 123.21 | Bangladesh | Christchurch | 13-Oct-2022 |
| 60 | Babar Azam | 69 | 44 | 6 | 2 | 156.81 | New Zealand | Lahore | 27-Apr-2024 |
| 61 | Babar Azam | 68 | 55 | 5 | 1 | 123.63 | Australia | Abu Dhabi | 24-Oct-2018 |
| 62 | Babar Azam | 68 | 52 | 6 | 2 | 130.76 | India | Dubai (DICS) | 24-Oct-2021 |
| 63 | Haider Ali | 68 | 39 | 6 | 4 | 174.35 | West Indies | Karachi | 13-Dec-2021 |
| 64 | Mohammad Rizwan | 68 | 46 | 6 | 2 | 147.82 | England | Karachi | 20-Sep-2022 |
| 65 | Salman Butt | 67 | 54 | 8 | 1 | 124.07 | New Zealand | Bridgetown | 08-May-2010 |
| 66 | Mohammad Hafeez | 67 | 49 | 9 | 1 | 136.73 | Bangladesh | Lahore | 25-Jan-2020 |
| 67 | Mohammad Rizwan | 67 | 52 | 3 | 4 | 128.84 | Australia | Dubai (DICS) | 11-Nov-2021 |
| 68 | Misbah-ul-Haq | 66 | 42 | 7 | 1 | 157.14 | Australia | Johannesburg | 18-Sep-2007 |
| 69 | Babar Azam | 66 | 44 | 7 | 1 | 150.00 | Bangladesh | Lahore | 25-Jan-2020 |
| 70 | Haider Ali | 66 | 43 | 6 | 3 | 153.48 | Zimbabwe | Rawalpindi | 08-Nov-2020 |
| 71 | Babar Azam | 66 | 47 | 5 | 3 | 140.42 | Scotland | Sharjah | 07-Nov-2021 |
| 72 | Babar Azam | 66 | 46 | 6 | 2 | 143.47 | Australia | Lahore | 05-Apr-2022 |
| 73 | Babar Azam | 66 | 43 | 7 | 2 | 153.48 | New Zealand | Hamilton | 14-Jan-2024 |
| 74 | Shan Masood | 65 | 40 | 3 | 4 | 162.50 | England | Karachi | 23-Sep-2022 |
| 75 | Babar Azam | 65 | 42 | 5 | 3 | 154.76 | England | Cardiff | 05-May-2019 |